Proteintech

HOIP Polyclonal Antibody

HOIP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HOIP Antibody (16289-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 16289-1-AP ( HOIP antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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产品信息

16289-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:1,000

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免疫组化（石蜡） (IHC (P))

1:50-1:500

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

HOIP Fusion Protein Ag9440 (258-603 aa encoded by BC017376)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: RQHFTIALK EKHITDMVCP ACGRPDLTDD TQLLSYFSTL DIQLRESLEP DAYALFHKKL TEGVLMRDPK FLWCAQCSFG FIYEREQLEA TCPQCHQTFC VRCKRQWEEQ HRGRSCEDFQ NWKRMNDPEY QAQGLAMYLQ ENGIDCPKCK FSYALARGGC MHFHCTQCRH QFCSGCYNAF YAKNKCPEPN CRVKKSLHGH HPRDCLFYLR DWTALRLQKL LQDNNVMFNT EPPAGARAVP GGGCRVIEQK EVPNGLRDEA CGKETPAGYA GLCQAHYKEY LVSLINAHSL DPATLYEVEE LETATERYLH VRPQPLAGED PPAYQARLLQ KLTEEVPLGQ SIPRRRK (258-603 aa encoded by BC017376 )

靶标信息

Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: E3 ubiquitin-protein ligase RNF31; FLJ23501; HOIL-1-interacting protein; HOIP; MGC19975; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; Zinc in-between-RING-finger ubiquitin-associated domain protein

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基因别名: HOIP; RNF31; ZIBRA

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UniProt ID: (Human) Q96EP0

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Entrez Gene ID: (Human) 55072

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功能

ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity ubiquitin protein ligase binding ubiquitin binding ubiquitin-protein ligase protein modifying enzyme

参与通路

protein polyubiquitination I-kappaB kinase/NF-kappaB signaling regulation of tumor necrosis factor-mediated signaling pathway CD40 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity protein linear polyubiquitination positive regulation of protein targeting to mitochondrion