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Immunogen sequence: EYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC TVQRYAACRD PG (22-72 aa encoded by BC049204)
HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: homeo box 2F; homeo box B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; Homeobox protein Hox-B4
基因别名: HOX-2.6; HOX2; HOX2F; HOXB4
UniProt ID: (Human) P17483
Entrez Gene ID: (Human) 3214