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产品信息
CF810941
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
OTI1E3
抗原
Human recombinant protein fragment corresponding to amino acids 69-290 of human HOXD8 (NP_062458) produced in E.coli.
偶联物
形式
Lyophilized
浓度
See Label
纯化类型
Protein A/G
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
靶标信息
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box 4E; homeo box D8; homeobox protein 5.4; Homeobox protein Hox-4.3; Homeobox protein Hox-4E; Homeobox protein Hox-5.4; Homeobox protein Hox-D8; Hox-4.5
基因别名: 4921540P06Rik; AI047735; Hox-4.3; Hox-5.4; HOX4; HOX4E; HOX5.4; Hoxd-8; HOXD8
UniProt ID: (Human) P13378, (Mouse) P23463
Entrez Gene ID: (Human) 3234, (Mouse) 15437
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
anterior/posterior pattern specification
positive regulation of transcription from RNA polymerase II promoter
skeletal system morphogenesis
anterior/posterior axis specification, embryo
