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Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2-O-sulfotransferase; 2-OST; 2OST; Heparan sulfate 2-O-sulfotransferase 1
基因别名: AW214369; dJ604K5.2; HS2ST; HS2ST1; KIAA0448; mKIAA0448
UniProt ID: (Human) Q7LGA3, (Mouse) Q8R3H7
Entrez Gene ID: (Human) 9653, (Mouse) 23908