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PA1-29463 detects 5-HT1B receptor from rat, mouse, and human samples.
PA1-29463 has been successfully used in Western blot applications. Western blot detects a band ~40-41 kDa. Possible positive controls for this product are human, mouse or rat brain.
The PA1-29463 immunogen is: Synthetic peptides, corresponding to amino acids 8-26 (CAPPPPAGSETWVPQANLS) and 263-278 (STSSVTSINSRVPDVP) of 5HT1B Receptor.
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
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