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Hopx Antibody (PA5-49449) in WB
Western blot analysis of Hopx in various lysates. Samples were incubated with Hopx polyclonal antibody (Product # PA5-49449) using a dilution of 1:1,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: Mouse lung tissue lysate; Lane 2: Rat lung tissue lysate. Predicted band size: 8 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
产品信息
PA5-49449
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 22-54 amino acids from the Central region of Mouse Hopx.
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2634903
靶标信息
HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GIIg15b; global ischemia induced protein GIIG15B; Global ischemia-induced gene 15B protein; global ischemia-induced protein 15B; homeobox only domain; Homeobox-only protein; homeodomain only protein; Homeodomain-only protein; Lung cancer-associated Y protein; mOB1; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; odd homeobox 1; Odd homeobox protein 1
基因别名: 1110018K11Rik; 1200015P04Rik; 2300002F06Rik; AI848177; AW490897; CAMEO; GIIg15b; Hdop; HOD; HOP; HOPX; LAGY; NECC1; OB1; Obl; SMAP31; TOTO
UniProt ID: (Human) Q9BPY8, (Mouse) Q8R1H0, (Rat) Q78ZR5
Entrez Gene ID: (Human) 84525, (Mouse) 74318, (Rat) 171160
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
heart development
regulation of heart contraction
histone deacetylation
regulation of protein binding
positive regulation of skeletal muscle tissue regeneration
negative regulation of cell differentiation
lung alveolus development
positive regulation of striated muscle cell differentiation
regulation of transcription from RNA polymerase II promoter
