Proteintech

Hsc70 Monoclonal Antibody (1A4B3)

Hsc70 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 6

Hsc70 Antibody (66442-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293 cells using Hsc70 antibody (Product # 66442-1-IG, Clone: 1A4B3 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

Hsc70 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

产品信息

66442-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:3000-1:20,000

查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫细胞化学 (ICC/IF)

Assay-dependent

查看1篇已发表文章 1篇已发表文章

不适用 (N/A)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Pig

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1A4B3

抗原

Hsc70 Fusion Protein Ag17910 (346-646 aa encoded by BC007276)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: QKLLQDFFN GKELNKSINP DEAVAYGAAV QAAILSGDKS ENVQDLLLLD VTPLSLGIET AGGVMTVLIK RNTTIPTKQT QTFTTYSDNQ PGVLIQVYEG ERAMTKDNNL LGKFELTGIP PAPRGVPQIE VTFDIDANGI LNVSAVDKST GKENKITITN DKGRLSKEDI ERMVQEAEKY KAEDEKQRDK VSSKNSLESY AFNMKATVED EKLQGKINDE DKQKILDKCN EIINWLDKNQ TAEKEEFEHQ QKELEKVCNP IITKLYQSAG GMPGGMPGGF PGGGAPPSGG ASSGPTIEEV D (346-646 aa encoded by BC007276)

靶标信息

The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.

Ecotoxicology and environmental safety

Zhang H,Xie Z,Peng Y,Xie A,Fu C,Zheng D,Cai Z,Zhong J,Ming Q,Li M,Lu R,Liu X,Chen J

Wed Mar 01 00:00:00 EST 2023

A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates.

FEBS open bio

Suzuki M,Yamamoto Y,Nishijima-Matsunobu A,Kawasaki Y,Shibata H,Omori Y

Wed Mar 01 00:00:00 EST 2023

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization.

Microbiology spectrum

Wang L,Li R,Geng R,Zhang L,Chen XX,Qiao S,Zhang G

Wed Feb 23 00:00:00 EST 2022

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization.

Microbiology spectrum

Wang L,Li R,Geng R,Zhang L,Chen XX,Qiao S,Zhang G

Wed Feb 23 00:00:00 EST 2022

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization.

Microbiology spectrum

Wang L,Li R,Geng R,Zhang L,Chen XX,Qiao S,Zhang G

Wed Feb 23 00:00:00 EST 2022

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization.

Microbiology spectrum

Wang L,Li R,Geng R,Zhang L,Chen XX,Qiao S,Zhang G

Wed Feb 23 00:00:00 EST 2022

Integrative Proteomics and Transcriptomics Profiles of the Oviduct Reveal the Prolificacy-Related Candidate Biomarkers of Goats (Capra hircus) in Estrous Periods.

International journal of molecular sciences

Sun Z,Liu Y,He X,Di R,Wang X,Ren C,Zhang Z,Chu M

Mon Nov 28 00:00:00 EST 2022

Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.

Cell communication and signaling : CCS

Wang Y,Zhang B,Wang J,Wu H,Xu S,Zhang J,Wang L

Wed Mar 24 00:00:00 EDT 2021

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.

Journal of neuroinflammation

Chen J,Mao K,Yu H,Wen Y,She H,Zhang H,Liu L,Li M,Li W,Zou F

Mon Dec 20 00:00:00 EST 2021

生物信息学

蛋白别名: AAG2; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; FAM10A1; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; heat shock cognate hsc73; heat shock cognate protein 54; Heat shock cognate protein 70; heat shock protein 8; heat shock protein A8; heat shock protein cognate 70; Heat shock protein family A member 8; LAP-1; Lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; SNC6

查看更多收起

基因别名: 2410008N15Rik; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; Hsc73; HSP71; HSP73; HSPA10; HSPA8; LAP-1; LAP1; NIP71

查看更多收起

UniProt ID: (Human) P11142, (Rat) P63018, (Mouse) P63017

查看更多收起

Entrez Gene ID: (Human) 3312, (Rat) 24468, (Mouse) 15481

查看更多收起

功能