Bethyl Laboratories

Human Lactoferrin Polyclonal Antibody

产品信息

A80-144A

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000 - 1:30,000

免疫组化（石蜡） (IHC (P))

1:100 - 1:500

免疫细胞化学 (ICC/IF)

1:100 - 1:500

酶联免疫吸附实验 (ELISA)

1:1,000 - 1:30,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 6.8 to 7.4

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Goats were immunized with purified human lactoferrin human milk. Antiserum was solid phase adsorbed to ensure specificity. The antibody was isolated by affinity chromatography using antigen coupled to agarose beads. Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

靶标信息

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; neutrophil lactoferrin; Talalactoferrin

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基因别名: GIG12; HEL110; HLF2; LF; LTF

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UniProt ID: (Human) E7EQH5

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Entrez Gene ID: (Human) 4057

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功能

DNA binding serine-type endopeptidase activity iron ion binding protein binding heparin binding protein serine/threonine kinase activator activity transfer/carrier protein

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