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IBA1 Antibody (PA5-18488) in ICC/IF
Immunocytochemistry analysis of IBA1 using IBA1 Polyclonal Antibody (Product # PA5-18488) in paraformaldehyde fixed CaCo-2 cells immobilized on Shi-fix™ coverslip, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing plasma membrane and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-18488
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (NKQFLDDPKYSSDED) corresponding to the internal amino acids of AIF1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10986948
产品详细信息
This antibody is predicted to react with canine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
靶标信息
AIF1 is induced by cytokines and interferon. It is thought to be involved in the negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIF-1; Allograft inflammatory factor 1; DADB-70P7.8; DASS-82G15.2; Em:AF129756.17; Iba; interferon gamma responsive transcript; Ionized calcium-binding adapter molecule 1; Protein G1
基因别名: AIF-1; AIF1; G1; IBA1; IRT-1; IRT1
UniProt ID: (Human) P55008
Entrez Gene ID: (Human) 199
microglial cell activation
positive regulation of protein phosphorylation
phagocytosis, engulfment
inflammatory response
negative regulation of gene expression
positive regulation of muscle hyperplasia
Rac protein signal transduction
actin filament polymerization
cellular response to extracellular stimulus
cellular response to hormone stimulus
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
response to axon injury
actin filament bundle assembly
response to glucocorticoid
response to electrical stimulus
cellular response to morphine
cellular response to interferon-gamma
cellular response to hydroperoxide
negative regulation of smooth muscle cell chemotaxis
positive regulation of smooth muscle cell chemotaxis
positive regulation of monocyte chemotaxis
ruffle assembly
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of T cell migration
