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产品信息
PA5-120684
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human IFI16 (NP_0013517961)
偶联物
形式
Liquid
浓度
3.21 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914256
产品详细信息
Positive test controls include: HeLa, MCF7, NIH/3T3, THP-1, Mouse ovary, Mouse spleen, Rat ovary. The target is usually found in the following locations: Cytoplasm, Nucleus.
Immunogen sequence: MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD LMEEKFRGDA GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK EVDATSPAPS TSSTVKTEGA EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS STENPKTVAK CQVTPRRNVL QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF HVKVLNTSLK EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE
靶标信息
IFI16 (gamma-inteferon-inducible protein 16) binds double-stranded DNA. It binds preferentially to supercoiled DNA and cruciform DNA structures. It seems to be involved in transcriptional regulation and as a transcriptional repressor. IFI16 may have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. It controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. IFI16 is also involved in innate immune response by recognizing viral dsDNA in the cytosol and nucleus. After binding to viral DNA in the cytoplasm, IFI16 recruits TMEM173/STING and mediates the induction of IFN-beta. It is necessary to activate the IFR3 signaling cascade suring human herpes simplex virus 1 infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibiton of viral immediate-early gene expression and replication. IFI16 is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Gamma-interferon-inducible protein 16; IFI 16C; Ifi-16; interferon, gamma-inducible protein 16; interferon-gamma induced protein IFI 16; Interferon-inducible myeloid differentiation transcriptional activator
基因别名: IFI16; IFNGIP1; PYHIN2
UniProt ID: (Human) Q16666
Entrez Gene ID: (Human) 3428
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
double-stranded DNA binding
protein binding
transcription factor binding
poly(A) RNA binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cytokine production
activation of innate immune response
transcription, DNA-templated
autophagy
inflammatory response
cell proliferation
regulation of autophagy
hemopoiesis
myeloid cell differentiation
monocyte differentiation
positive regulation of type I interferon production
positive regulation of interleukin-1 beta production
regulation of gene expression, epigenetic
cellular response to glucose starvation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of DNA binding
negative regulation of viral genome replication
innate immune response
negative regulation of innate immune response
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
cellular response to ionizing radiation
intrinsic apoptotic signaling pathway by p53 class mediator
activation of cysteine-type endopeptidase activity
negative regulation of cysteine-type endopeptidase activity
