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产品信息
PA5-50175
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from C-terminal of human IFI6.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2635628
产品详细信息
The antibody detects endogenous levels of total IFI6 protein.
靶标信息
G1P3, also known as Interferon alpha-inducible protein 6 (IFI6) and Interferon-induced protein 6-16, is a 130 amino acid member of the IFI6 family of proteins. Localized to the mitochondria, G1P3 is a multi-pass membrane protein that is induced by IFN-α2β. G1P3 has been shown to play a major role in the apoptosis pathway. Specifically, G1P3 acts as a cell survival protein by inhibiting caspase-3 activity, which antagonizes apoptosis. G1P3 has been implicated in tumorigenesis and is the subject of therapeutic studies, as reducing G1P3-mediated antiapoptotic signals could suggest improved therapies for myeloma or other malignancies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ifi-6-16; Interferon alpha-inducible protein 6; interferon, alpha-inducible protein 6; interferon, alpha-inducible protein clone IFI-6-16; Interferon-induced protein 6-16
基因别名: 6-16; FAM14C; G1P3; IFI-6-16; IFI6; IFI616
UniProt ID: (Human) P09912
Entrez Gene ID: (Human) 2537
release of cytochrome c from mitochondria
immune response
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of mitochondrial depolarization
type I interferon signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
