Invitrogen

IFITM3 Polyclonal Antibody

IFITM3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IFITM3 Antibody (PA5-143274) in IHC (P)

Immunohistochemistry analysis of IFITM3 in Human Spleen (Formalin-Fixed, Paraffin-Embedded). Samples were incubated with IFITM3 polyclonal antibody (Product # PA5-143274).

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产品信息

PA5-143274

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.3-1 µg/mL

免疫组化（石蜡） (IHC (P))

2.5 µg/mL

产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide with sequence HTVQTFFSPVNS-C.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2933913

产品详细信息

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

靶标信息

IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-alpha and IFN-gamma. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。