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Invitrogen
IFITM3 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 7
IFITM3 Antibody (PA5-34598) in ICC/IF
Immunofluorescence analysis of IFITM3 was performed using 70% confluent log phase MCF-7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with IFITM3 Polyclonal Antibody (Product # PA5-34598) at 10 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790)... View More
产品信息
PA5-34598
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from residues 1 - 50 of Mouse Fragilis.
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551950
产品详细信息
Immunohistochemistry has been used succesfully with glycolmethacrylate sections.
靶标信息
IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-alpha and IFN-gamma. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Dispanin subfamily A member 2b; DSPA2b; Fragilis; Fragilis 3; Fragilis protein; ifitm-like protein 1; Interferon-induced transmembrane protein 3; Interferon-inducible protein 15; interferon-inducible protein variant 10; Mil-1; Mouse ifitm-like protein 1
基因别名: 1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls; Ifitm3; IP15; mil-1; rat8
UniProt ID: (Rat) P26376, (Mouse) Q9CQW9
Entrez Gene ID: (Rat) 361673, (Mouse) 66141
receptor-mediated endocytosis
heart development
negative regulation of cell proliferation
response to virus
negative regulation of viral transcription
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
negative regulation of viral entry into host cell
defense response to virus
cardiac muscle cell differentiation
type I interferon signaling pathway
immune system process
response to biotic stimulus
innate immune response
