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IGF1R alpha Antibody (MA5-13817) in ICC/IF
Knockdown of Insulin-like growth factor 1 receptor was achieved by transfecting MCF7 cells with Insulin-like growth factor 1 receptor specific siRNA (Silencer® select Product # S7213, S7211). Immunofluorescence analysis was performed on untransfected MCF7 cells (panel a,d), transfected with non-specific scrambled siRNA (panels b,e) and transfected with Insulin-like growth factor 1 receptor specific siRNA (p... View More
产品信息
MA5-13817
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
24-60
抗原
IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
偶联物
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10986755
产品详细信息
MA5-13817 targets IGF-1 Receptor alpha in IA, ICC/IF, WB and IP applications and shows reactivity with Human and Mouse samples.
The MA5-13817 immunogen is iGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA.
靶标信息
IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
