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The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp781H1425; Elongator complex protein 1; ELP1; FLJ12497; IkappaB kinase complex-associated protein; IKK complex-associated protein; IKK-complex-associated protein IKAP; inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein; RP11-3J11.4
基因别名: 3110040G09Rik; 6030413P05; C78473; Elp1; IKAP; Ikbkap
UniProt ID: (Mouse) Q7TT37, (Rat) Q8VHU4
Entrez Gene ID: (Mouse) 230233, (Rat) 140934
分子生物学功能:
RNA metabolism protein
nucleic acid metabolism protein
general transcription factor