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Application
产品信息
PA5-58491
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human IKBIP. Recombinant protein control fragment (Product #RP-97813).
偶联物
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2642682
产品详细信息
Immunogen sequence: LESTESILQE ATSSMSLMTQ FEQEVSNLQD IMHDIQNNEE VLTQRMQSLN EKFQNITDFW KRSLEEMNIN TDIFKSEAKH IHSQVTVQIN
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 72%.
靶标信息
IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle.
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生物信息学
蛋白别名: I kappa B kinase interacting protein; I kappa-B kinase-interacting protein; IKBKB-interacting protein; IKK interacting protein; IKK-interacting protein; Inhibitor of nuclear factor kappa-B kinase-interacting protein
基因别名: IKBIP; IKIP
UniProt ID: (Human) Q70UQ0
Entrez Gene ID: (Human) 121457
