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产品信息
CF804396
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
OTI7E11
抗原
Human recombinant protein fragment corresponding to amino acids 1-301 of human IKZF3 produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IKAROS family zinc finger 3 (Aiolos); Ikaros family zinc finger protein 3; zinc finger DNA binding protein Aiolos; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos)
基因别名: AIO; AIOLOS; IKZF3; ZNFN1A3
UniProt ID: (Human) Q9UKT9
Entrez Gene ID: (Human) 22806
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
metal ion binding
protein heterodimerization activity
C2H2 zinc finger transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mesoderm development
regulation of B cell proliferation
B cell activation
regulation of apoptotic process
regulation of B cell differentiation
regulation of lymphocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
