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产品信息
BS-2603R
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from mouse IL-12RB1, amino acids 401-500.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component); Interleukin-12 receptor subunit beta-1; MGC34454
基因别名: CD212; IL-12R[b]; Il12rb; Il12rb1
UniProt ID: (Mouse) Q60837
Entrez Gene ID: (Rat) 171333, (Mouse) 16161
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
peptidyl-tyrosine phosphorylation
positive regulation of interferon-gamma production
interleukin-12-mediated signaling pathway
interleukin-23-mediated signaling pathway
positive regulation of activated T cell proliferation
cellular response to interferon-gamma
