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Description: This polyconal Anti-Mouse IL-28 antibody reacts with mouse interleukin-28 (IL-28), a member of the IFN-lambda family which mediates the induction of anti-viral protection in a wide variety of cells.
Applications Reported: This polyclonal Anti-Mouse IL-28 antibody has been reported for use in ELISA detection of mouse IL-28.
Applications Tested: This polyclonal Anti-Mouse IL-28 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of mouse IL-28 in combination with the purified RN28 (cat. 14-7281) antibody for capture. A suitable range of concentrations of this antibody for ELISA detection is 2-6 µg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 4000 pg/mL - 30 pg/mL should be included in each ELISA plate.
Filtration: 0.2 µm post-manufacturing filtered.
IL28 is a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
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