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IL-28A/IL-28B Antibody (MA5-23902) in Neu
Neutralization of IL-28A/IL-28B in HepG2 human hepatocellular carcinoma cell line. Samples were incubated in IL-28A/IL-28B monoclonal antibody (Product # MA5-23902). Recombinant Mouse IL‚28B/IFN‚λ3 reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse IL‚28B/IFN‚λ3 (400 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL‚28B/IFN‚λ3 Monoclonal Ant... View More
产品信息
MA5-23902
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
244716
抗原
E. coli-derived recombinant mouse IL-28B/IFN-lambda3 Asp20-Val193
偶联物
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2607558
产品详细信息
In sandwich ELISAs, 100% cross-reactivity with recombinant mouse IL-28A/IFN-lambda 2 and no cross-reactivity with recombinant human (rh) IL-28A or rhIL-29 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
IL28 is a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IFN lambda2; IFN-lambda-2; IFN-lambda-3; IFN-lambda2; IL 28; IL 28 A; IL-28A; IL-28B; ILN; interferon alpha; Interferon lambda-2; Interferon lambda-3; Interferon lambda2; interferon-lambda2; Interleukin; interleukin 28; interleukin 28A; interleukin 28B; Interleukin-28A; Interleukin-28B
基因别名: EG330496; IFL-1; Ifnl2; Ifnl3; IL-28A; IL-28B; Il28; Il28a; Il28b; INF-alpha; INF-lambda
UniProt ID: (Mouse) Q4VK74, (Mouse) Q8CGK6
Entrez Gene ID: (Mouse) 330496, (Mouse) 338374
