Invitrogen

IL23R Polyclonal Antibody

查看其他14个IL23R抗体

产品信息

PA5-72940

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-1.0 µg/mL

-

免疫组化 (IHC)

5-10 µg/mL

-

流式细胞分析 (Flow)

1:10-1:1,000

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide located at amino acids 439-455 of human IL-23R (NP_653302).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2718794

靶标信息

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: IBD17; IL 23R; IL-23 receptor; Interleukin-23 receptor

查看更多收起

基因别名: IL-23R; IL23R

查看更多收起

UniProt ID: (Human) Q5VWK5, (Mouse) Q8K4B4

查看更多收起

Entrez Gene ID: (Human) 149233, (Mouse) 209590

查看更多收起

interleukin-12 receptor binding protein binding interleukin-23 binding interleukin-23 receptor activity transmembrane signal receptor

参与通路

positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host positive regulation of T-helper 1 type immune response inflammatory response positive regulation of activation of JAK2 kinase activity response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of natural killer cell proliferation response to interferon-gamma interleukin-23-mediated signaling pathway positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat4 protein positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of memory T cell differentiation positive regulation of osteoclast differentiation defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment immune system process leukocyte mediated immunity JAK-STAT cascade cytokine-mediated signaling pathway innate immune response