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产品信息
TA809390
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI3C5
抗原
Human recombinant protein fragment corresponding to amino acids 52-206 of human IL24 produced in E.coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IL 24; IL-24; IL-4-induced secreted protein; Interleukin-24; MDA-7; melanocyte-associated Mda-7; Melanoma differentiation-associated gene 7 protein; suppression of tumorigenicity 16 (melanoma differentiation); Suppression of tumorigenicity 16 protein
基因别名: C49A; FISP; IL10B; IL24; MDA7; MOB5; ST16
UniProt ID: (Human) Q13007
Entrez Gene ID: (Human) 11009
apoptotic process
inflammatory response
immune response
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of cell migration
serine phosphorylation of STAT3 protein
wound healing
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of JAK-STAT cascade
cellular response to lipopolysaccharide
cellular response to interleukin-4
