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This antibody detects endogenous protein at a molecular weight of 88 kDa.
Purity is >95% by SDS-PAGE.
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD124; il-4 receptor; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4R nirs variant 1; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; Interleukin-4 receptor subunit alpha
基因别名: 582J2.1; CD124; IL-4RA; IL4R; IL4RA
UniProt ID: (Human) P24394, (Rat) Q63257, (Mouse) P16382
Entrez Gene ID: (Human) 3566, (Rat) 25084, (Mouse) 16190