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IL5RA Antibody (MA5-23621) in Flow
Flow cytometry of IL5RA in HEK293 human embryonic kidney cell line transfected with (A) human IL‚5 Rα/CD125 or (B) irrelevant transfectants and eGFP. Samples were incubated in IL5RA monoclonal antibody (Product # MA5-23621). Quadrant markers were set based on control antibody staining.
产品信息
MA5-23621
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
26815
抗原
Sf 21-derived recombinant human IL-5R alpha/CD125 Asp21-Arg335
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
Buffered saline solution with BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608179
产品详细信息
In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) IL-5 R beta, rhIL-9 R, rhIL-4 R, recombinant mouse IL-5 R alpha, or rhIL-13 R alpha 1.
靶标信息
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD125; CD125 antigen; CDw125; IL-5 receptor subunit alpha; IL-5R subunit alpha; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; Interleukin-5 receptor subunit alpha
基因别名: CD125; CDw125; HSIL5R3; IL5R; IL5RA
UniProt ID: (Human) Q14633
Entrez Gene ID: (Human) 3568
