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产品信息
PA5-50818
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide of human inhibin, beta B
偶联物
Unconjugated
形式
Liquid
浓度
2.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636270
产品详细信息
The antibody detects endogenous levels of total INHBB protein.
靶标信息
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activin AB beta polypeptide; Activin beta-B chain; activin betaB; Inhibin beta B chain; inhibin beta subunit B; inhibin, beta B; Inhibin, beta-2
基因别名: INHBB
UniProt ID: (Human) P09529, (Mouse) Q04999, (Rat) P17491
Entrez Gene ID: (Human) 3625, (Mouse) 16324, (Rat) 25196
ovarian follicle development
defense response
cellular response to starvation
response to mechanical stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
cellular response to insulin stimulus
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
cellular response to leptin stimulus
fat cell differentiation
negative regulation of insulin secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
negative regulation of hepatocyte growth factor biosynthetic process
cell development
oocyte development
positive regulation of ovulation
SMAD protein signal transduction
positive regulation of apoptotic signaling pathway
eye development
cellular response to cholesterol
spermatogenesis
male gonad development
response to organic cyclic compound
response to insecticide
pituitary gland development
response to gonadotropin
cellular response to cAMP
cellular response to interleukin-1
cellular response to organic cyclic compound
cellular response to thyroid hormone stimulus
