Search Thermo Fisher Scientific
The antibody detects endogenous levels of total INHBB protein.
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: activin AB beta polypeptide; Activin beta-B chain; activin betaB; Inhibin beta B chain; inhibin beta subunit B; inhibin, beta B; Inhibin, beta-2
基因别名: INHBB
UniProt ID: (Human) P09529, (Mouse) Q04999, (Rat) P17491
Entrez Gene ID: (Human) 3625, (Mouse) 16324, (Rat) 25196