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Immunogen sequence: MDQSVAIQE TLAEGEYCVI AVQGVLCEGD SRQSRLLGLV RYRLEHGGQE HALFLYTHRR MAITGDDVSL DQIVPVSRDF TLEEVSPDGE LYILGSDVTV QLDTAELSLV FQLPFGSQTR MFLHEVARAC PGFDSATRDP EFLWLSRYRC AELELEMPTP RGCNSALVTW PGYATIGGGG SNFDGLRPNG KGVPMDQSSR GQDKPESLQP RQNKSKSEIT DMVRSSTITV SDKAHILSMQ KFGLRDTIVK SHLLQKEEDY TYIQNFRFFA GTYNVNGQSP KECLRLWLSN GIQAPDVYCV GFQELDLSKE (1-309 aa encoded by BC058932)
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 5PTase; 75 kDa inositol polyphosphate-5-phosphatase; Inositol polyphosphate-5-phosphatase B; inositol polyphosphate-5-phosphatase, 75kDa; MGC65156; MGC71303; Phosphoinositide 5-phosphatase; RP11-109P14.7; Type II inositol 1,4,5-trisphosphate 5-phosphatase; type II inositol-1
基因别名: 5PTase; AW260155; INPP5B; INPP5P; OCRL2
UniProt ID: (Human) P32019, (Mouse) Q8K337
Entrez Gene ID: (Human) 3633, (Mouse) 16330, (Rat) 362590