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INPPL1/SHIP2 Antibody (A300-574A) in IHC
Detection of human expndtw-6 INPPL1/SHIP2 by immunohistochemistry. Sample: FFPE serial sections of human colon carcinoma. Antibody: Affinity purified rabbit anti-expndtw-6 INPPL1/SHIP2 Cat. No. A300-574A Lot 1 (left) and Lot 2 (right) used at a dilution of 1:1,000 (1µg/ml). Detection: DAB.
产品信息
A300-574A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residues 100 and 150 of human inositol polyphosphate phosphatase-like 1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 or Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat
靶标信息
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodeling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 51C protein; ablSH3-binding protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2
基因别名: 51C; INPPL1; OPSMD; SHIP2
UniProt ID: (Human) O15357, (Mouse) Q6P549
Entrez Gene ID: (Human) 3636, (Mouse) 16332
actin binding
protein binding
SH3 domain binding
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
SH2 domain binding
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate binding
hydrolase activity
endochondral ossification
immune system process
glucose metabolic process
phosphatidylinositol biosynthetic process
endocytosis
actin filament organization
cell adhesion
negative regulation of cell proliferation
post-embryonic development
negative regulation of gene expression
response to insulin
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
ruffle assembly
negative regulation of DNA replication
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of neuron projection development
dephosphorylation
inositol trisphosphate metabolic process
negative regulation of MAP kinase activity
negative regulation of insulin-like growth factor receptor signaling pathway
cellular lipid metabolic process
negative regulation of insulin receptor signaling pathway
