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Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: DTNTAQRMAL GVAAINQAIK EGKAAQTERV LRNPAVALRG VVPDCANGYQ RALESAMAKK QRPADTAFWV QHDMKDGTAY YFHLQTFQGI WEQPPGC
IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: IQGA3; MGC10170; Ras GTPase-activating-like protein IQGAP3
基因别名: IQGAP3
UniProt ID: (Human) Q86VI3
Entrez Gene ID: (Human) 128239
分子生物学功能:
G-protein modulator
protein-binding activity modulator
GTPase-activating protein