Bioss

IRS-2 Polyclonal Antibody

查看其他13个IRS2抗体

抗体检测数据 (2)

IRS-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IRS-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IRS-2 Antibody (BS-0173R) in IHC (P)

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti IRS-2 Polyclonal Antibody, Unconjugated (bs-0173R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

IRS-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IRS-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

IRS-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti IRS-2 Polyclonal Antibody, Unconjugated (bs-0173R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

IRS-2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded: rat skeletal muscle labeled with Anti-IRS2 Polyclonal Antibody (bs-0173R), Unconjugated at 1:200followed by conjugation to the secondary antibody and DAB staining.

产品信息

BS-0173R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

-

免疫组化（石蜡） (IHC (P))

1:200

-

免疫组化（冰冻） (IHC (F))

1:100-1:500

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

流式细胞分析 (Flow)

1:20-1:100

-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human IRS-2, amino acids 501-600.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 4PS; Insulin receptor substrate 2; IRS-2; tyrosine kinase substrate

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基因别名: 4PS; IRS-2; IRS2

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UniProt ID: (Human) Q9Y4H2, (Mouse) P81122

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Entrez Gene ID: (Human) 8660, (Rat) 29376, (Mouse) 384783

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signal transducer activity Ras guanyl-nucleotide exchange factor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein phosphatase binding protein domain specific binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 14-3-3 protein binding

参与通路

positive regulation of mesenchymal cell proliferation negative regulation of B cell apoptotic process brain development cell proliferation positive regulation of cell proliferation insulin receptor signaling pathway response to glucose negative regulation of plasma membrane long-chain fatty acid transport positive regulation of glucose metabolic process regulation of lipid metabolic process positive regulation of cell migration mammary gland development positive regulation of B cell proliferation positive regulation of fatty acid beta-oxidation positive regulation of insulin secretion cellular response to insulin stimulus negative regulation of kinase activity positive regulation of glycogen biosynthetic process positive regulation of glucose import cellular response to glucose stimulus cellular response to peptide signal transduction MAPK cascade glucose metabolic process regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol-3-phosphate biosynthetic process positive regulation of GTPase activity phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling lipid homeostasis