Invitrogen

ISL1 Polyclonal Antibody

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ISL1 Antibody in Western Blot (WB)

ISL1 Antibody in Western Blot (WB)

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ISL1 Antibody (PA5-49395) in WB

Western blot analysis of ISL1 in lysate from rat brain tissue. Samples were incubated with ISL1 polyclonal antibody (Product # PA5-49395) using a dilution of 1:1,000 followed by goat anti-rabbit IgG H&L (HRP) at a dilution of 1:10,000. Lysate at 20 µg.

ISL1 Antibody in Western Blot (WB)

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ISL1 Antibody in Western Blot (WB) — Western blot analysis of ISL1 in lysate from rat brain tissue. Samples were incubated with ISL1 polyclonal antibody (Product # PA5-49395) using a dilution of 1:1,000 followed by goat anti-rabbit IgG H&L (HRP) at a dilution of 1:10,000. Lysate at 20 µg.

产品信息

PA5-49395

应用

建议稀释比

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免疫印迹 (WB)

1:1,000

-

产品规格

种属反应

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 302-336 amino acids from the C-terminal region of mouse Isl1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2634849

产品详细信息

Predicted to react with chicken, zebrafish and human based on sequence homology.

靶标信息

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Insulin gene enhancer protein ISL-1; isl-1 homeobox; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain 1; Islet-1

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基因别名: Isl-1; isl-1=homeobox; Isl1

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UniProt ID: (Rat) P61374

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Entrez Gene ID: (Rat) 64444

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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity enhancer sequence-specific DNA binding DNA binding chromatin binding protein binding zinc ion binding ligand-dependent nuclear receptor binding estrogen receptor binding bHLH transcription factor binding sequence-specific DNA binding

参与通路

negative regulation of transcription from RNA polymerase II promoter neural crest cell migration heart morphogenesis secondary heart field specification outflow tract septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis regulation of secondary heart field cardioblast proliferation regulation of transcription, DNA-templated heart development positive regulation of cell proliferation regulation of gene expression positive regulation of vascular endothelial growth factor production spinal cord motor neuron cell fate specification spinal cord motor neuron differentiation visceral motor neuron differentiation trigeminal nerve development pituitary gland development neuron differentiation pancreas development axon regeneration retinal ganglion cell axon guidance positive regulation of insulin secretion positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of intracellular estrogen receptor signaling pathway positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of DNA binding negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter neuron fate commitment neuron fate specification mesenchymal cell differentiation sensory system development peripheral nervous system neuron development peripheral nervous system neuron axonogenesis negative regulation of inflammatory response ventricular cardiac muscle tissue morphogenesis pharyngeal system development cardiac muscle cell myoblast differentiation innervation atrial septum morphogenesis cardiac cell fate determination cellular response to glucocorticoid stimulus positive regulation of granulocyte colony-stimulating factor production negative regulation of protein homodimerization activity negative regulation of canonical Wnt signaling pathway positive regulation of macrophage colony-stimulating factor production