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Recommended positive controls: HepG2, HCT116, mouse brain, rat brain.
Predicted reactivity: Mouse (95%), Rat (96%), Pig (95%), Sheep (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ABri/ADan amyloid peptide; Bri; BRICHOS domain containing 2B; imBRI2; Immature BRI2; Integral membrane protein 2B; Integral membrane protein 2B (E25B protein); OTTHUMP00000018394; Protein E25B; RP11-196P14.1; Transmembrane protein BRI
基因别名: ABRI; AI256040; BRI; BRI2; BRICD2B; D14Sel6; E25B; E25BMM; E3-16; FBD; imBRI2; ITM2B; RDGCA
UniProt ID: (Human) Q9Y287, (Rat) Q5XIE8, (Mouse) O89051
Entrez Gene ID: (Human) 9445, (Rat) 290364, (Mouse) 16432