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Antibody detects endogenous levels of total Intersectin 1.
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EH and SH3 domains protein 1; EH domain and SH3 domain regulator of endocytosis 1; Eh domain, SH3 domain regulator of endocytosis 1; human intersectin-SH3 domain-containing protein SH3P17; intersectin (SH3 domain protein 1A); intersectin 1 (SH3 domain protein 1A); intersectin 1 (SH3 domain protein); intersectin 1 short form variant 3; intersectin 1 short form variant, 11; intersectin short form 2 variant 2; intersectin short variant 12; Intersectin-1; intersectin-L; MGC134948; MGC134949; SH3 domain-containing protein 1A; SH3P17; Src homology 3 domain-containing protein
基因别名: AA517634; AA545208; AI316805; AI839402; AI848451; Ehsh1; Ese1; ITSN; ITSN1; SH3D1A; SH3P17
UniProt ID: (Human) Q15811, (Mouse) Q9Z0R4, (Rat) Q9WVE9
Entrez Gene ID: (Human) 6453, (Mouse) 16443, (Rat) 29491
分子生物学功能:
guanyl-nucleotide exchange factor
membrane traffic protein
scaffold/adaptor protein