Bioss

Integrin Alpha 3 + Beta 1 Polyclonal Antibody

说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

BS-1057R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300
-

免疫组化（石蜡） (IHC (P))

1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50
-

流式细胞分析 (Flow)

1:20-1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Mixed KLH conjugated synthetic peptide derived from human Integrin Alpha 3 (976-1025/1051) + Beta 1 (35-47/798).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

alpha3beta1 integrin is a laminin receptor with apparently diverse functions. In epithelial cells it acts as a receptor for the basement membrane, whereas in neuronal and possibly tumor cells it mediates migration. Interactions of alpha3beta1 integrin with tetraspanin proteins may provide clues to how it transduces signals that affect cell behavior.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: alpha 3 subunit of VLA-3 receptor; antigen CD49C; antigen identified by monoclonal antibody J143; Beta OL; Beta oligodendroglia; CD29; CD49 antigen-like family member C; CD49c; Fibronectin receptor subunit beta; FRP-2; Galactoprotein B3; GAPB3; Glycoprotein IIa; GPIIA; integrin alpha 3; Integrin alpha-3; integrin beta 1; integrin beta 1 (fibronectin receptor beta); Integrin beta-1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); testicular tissue protein Li 96; testicular tissue protein Li 98; very late activation protein 3 receptor, alpha-3 subunit; very late activation protein, beta polypeptide; VLA-3 subunit alpha; VLA-4 subunit beta

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基因别名: 4633401G24Rik; AA407068; AA409975; AA960159; CD29; CD49C; ENSMUSG00000051907; FNRB; FRP-2; GAP-B3; GAPB3; Gm9863; GPIIA; ILNEB; ITGA3; ITGB1; MDF2; MSK12; MSK18; VCA-2; VL3A; VLA-BETA; VLA3a; VLAB

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UniProt ID: (Human) P26006, (Human) P05556, (Mouse) Q62470, (Mouse) Q8BVU1, (Rat) P49134

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Entrez Gene ID: (Human) 3675, (Human) 3688, (Rat) 360606, (Mouse) 16400, (Mouse) 16412, (Rat) 24511

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功能
glycoprotein binding fibronectin binding protease binding integrin binding protein binding collagen binding protein domain specific binding laminin binding metal ion binding protein heterodimerization activity virus receptor activity actin binding coreceptor activity protein kinase binding C-X3-C chemokine binding protein complex binding peptide binding cell adhesion molecule binding alpha-actinin binding collagen binding involved in cell-matrix adhesion cadherin binding involved in cell-cell adhesion receptor activity receptor binding kinase binding integrin
参与通路
neuron migration cell-matrix adhesion integrin-mediated signaling pathway heart development memory positive regulation of gene expression positive regulation of epithelial cell migration positive regulation of cell-substrate adhesion positive regulation of neuron projection development regulation of transforming growth factor beta receptor signaling pathway regulation of Wnt signaling pathway extracellular matrix organization lung development regulation of BMP signaling pathway negative regulation of cell projection organization response to gonadotropin negative regulation of Rho protein signal transduction exploration behavior response to drug skin development mesodermal cell differentiation leukocyte migration maternal process involved in female pregnancy nephron development positive regulation of establishment of protein localization to plasma membrane dendritic spine maintenance renal filtration G1/S transition of mitotic cell cycle in utero embryonic development cell fate specification tissue homeostasis cell migration involved in sprouting angiogenesis cellular calcium ion homeostasis cellular defense response homophilic cell adhesion via plasma membrane adhesion molecules leukocyte cell-cell adhesion calcium-independent cell-matrix adhesion transforming growth factor beta receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation germ cell migration visual learning regulation of collagen catabolic process response to activity cell migration formation of radial glial scaffolds B cell differentiation positive regulation of cell migration cell-substrate adhesion receptor internalization protein transport within lipid bilayer cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion positive regulation of apoptotic process stress fiber assembly positive regulation of MAPK cascade positive regulation of GTPase activity sarcomere organization negative regulation of neuron differentiation positive regulation of endocytosis viral entry into host cell axon extension dendrite morphogenesis positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response leukocyte tethering or rolling regulation of cell cycle cardiac muscle cell differentiation bicellular tight junction assembly cellular response to mechanical stimulus cellular response to vitamin D cellular response to low-density lipoprotein particle stimulus cellular response to ionizing radiation negative regulation of anoikis cell adhesion fusion of sperm to egg plasma membrane single-organism behavior neuron projection development negative regulation of cell differentiation positive regulation of neuron differentiation cardiac muscle tissue development response to nutrient levels response to transforming growth factor beta
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