Proteintech

Integrin beta-1 Polyclonal Antibody

Integrin beta-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 9

Integrin beta-1 Antibody (12594-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using (Product # 12594-1-AP) (Integrin Beta 1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Integrin beta-1 Antibody in Western Blot (WB)

Product Image Gallery

产品信息

12594-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:8,000

查看31篇已发表文章 31篇已发表文章

免疫组化 (IHC)

查看9篇已发表文章 9篇已发表文章

免疫组化（石蜡） (IHC (P))

1:1,000-1:4,000

免疫细胞化学 (ICC/IF)

查看15篇已发表文章 15篇已发表文章

免疫沉淀 (IP)

查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

查看3篇已发表文章 3篇已发表文章

不适用 (N/A)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Deer, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Integrin beta-1 Fusion Protein Ag3078 (30-359 aa encoded by BC020057)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.65 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: ANAKSCGEC IQAGPNCGWC TNSTFLQEGM PTSARCDDLE ALKKKGCPPD DIENPRGSKD IKKNKNVTNR SKGTAEKLKP EDITQIQPQQ LVLRLRSGEP QTFTLKFKRA EDYPIDLYYL MDLSYSMKDD LENVKSLGTD LMNEMRRITS DFRIGFGSFV EKTVMPYIST TPAKLRNPCT SEQNCTSPFS YKNVLSLTNK GEVFNELVGK QRISGNLDSP EGGFDAIMQV AVCGSLIGWR NVTRLLVFST DAGFHFAGDG KLGGIVLPND GQCHLENNMY TMSHYYDYPS IAHLVQKLSE NNIQTIFAVT EEFQPVYKEL KNLIPKSAVG T (30-359 aa encoded by BC020057)

靶标信息

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins. ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins. Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue. Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease. Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta. More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. The distribution pattern in adult tissues for integrin beta types are mutually exclusive. Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Beta OL; Beta oligodendroglia; CD29; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; integrin beta 1; integrin beta 1 (fibronectin receptor beta); Integrin beta-1; Integrin beta1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; very late activation protein, beta polypeptide; VLA-4 subunit beta

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基因别名: 4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; FNRB; Gm9863; GPIIA; ITGB1; MDF2; MSK12; VLA-BETA; VLAB

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UniProt ID: (Human) P05556, (Mouse) Q8BVU1, (Rat) P49134

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Entrez Gene ID: (Human) 3688, (Mouse) 16412, (Rat) 24511

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