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Invitrogen
Involucrin Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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Involucrin Antibody (PA5-84245)
Relative expression in different tissues in IHC: Detection of differential expression levels of Involucrin demonstrates antibody specificity. Immunohistochemical analysis of Involucrin using anti-Involucrin Polyclonal Antibody (Product #PA5-84245), shows significant staining of Involucrin in esophagus and shows minimal or weak staining in stomach tissues. The relative expression levels of Involucrin within... View More
产品信息
PA5-84245
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.08 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2791397
产品详细信息
Immunogen sequence: QQHTLPVTLS PALSQELLKT VPPPVNTHQE QMKQPTPLPP PCQKVPVELP VEVPSKQEEK HMTAVKGLPE QECEQ
靶标信息
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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