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Invitrogen
Involucrin Monoclonal Antibody (SY8)
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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Involucrin Antibody (MA1-90573) in WB
Western blot was performed using Anti-Involucrin Monoclonal Antibody (SY8)(Product # MA1-90573) and a 68kDa band corresponding to Involucrin was observed across skin derived cell lines (HaCaT and A-431) and not in others. Whole Cell Extract-WCL (30 µg lysate) of HaCaT (Lane 1), A-431 (Lane 2), HeLa (Lane 3), MDA-MB-231 (Lane 4), Raji (Lane 5) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0301BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting S... View More
产品信息
MA1-90573
应用
建议稀释比
已发表文章
产品规格
种属反应
Avian,
Dog,
Human,
Non-human primate,
Pig
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
SY8
抗原
Pure involucrin from human keratinocytes.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2249265
产品详细信息
MA1-90573 detects Involucrin from non-human primate, porcine, and human samples.
靶标信息
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Involucrin
基因别名: IVL
UniProt ID: (Human) P07476, (Pig) P18175
Entrez Gene ID: (Dog) 102152041, (Human) 3713, (Pig) 407242
