NeoBiotechnologies

Involucrin Recombinant Mouse Monoclonal Antibody (rIVRN, 827)

Involucrin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Involucrin Antibody (3713-MSM4-P1ABX) in IHC (P)

Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human skin using Involucrin Recombinant Monoclonal Antibody (Product # 3713-MSM4-P1ABX).

Involucrin Antibody in SDS-PAGE (SDS-PAGE)

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产品信息

3713-MSM4-P1ABX

应用

建议稀释比

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免疫组化（石蜡） (IHC (P))

0.1-0.2 µg/mL

产品规格

种属反应

Dog, Human, Non-human primate, Pig

宿主/亚型

Mouse / IgG1, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

rIVRN, 827

抗原

Recombinant human full-length Involucrin protein (IVRN)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

This antibody does not react with Mouse.

Immunohistochemistry (PFA fixed): incubate antibody for 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

靶标信息

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。