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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AU016127; CD322; JAM-2; JAM-B; JAM-IT/VE-JAM; Junctional adhesion molecule 2; Junctional adhesion molecule B; RP23-253E17.2; Vascular endothelial junction-associated molecule; VE-JAM
基因别名: C21orf43; CD322; JAM-B; JAM2; JAMB; PRO245; UNQ219/PRO245; VE-JAM; VEJAM
UniProt ID: (Human) P57087
Entrez Gene ID: (Human) 58494