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产品信息
PA5-113675
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N terminal region of human JMJD3 (aa 2-51).
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2884190
产品详细信息
Immunogen sequence: HRAVDPPGAR AAREAFALGG LSCAGAWSSC PPHPPPRSAW LPGGRCSASI
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
靶标信息
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
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生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(27) demethylase 6B; JmjC domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase; Jumonji domain-containing protein 3; lysine (K)-specific demethylase 6B; Lysine demethylase 6B; Lysine-specific demethylase 6B
基因别名: JMJD3; KDM6B; KIAA0346
UniProt ID: (Human) O15054
Entrez Gene ID: (Human) 23135
inflammatory response to antigenic stimulus
response to activity
hippocampus development
cell fate commitment
endothelial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mesodermal cell differentiation
cardiac muscle cell differentiation
oxidation-reduction process
response to fungicide
cellular response to hydrogen peroxide
histone H3-K27 demethylation
