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Invitrogen
KDM5B Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-55535
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642981
产品详细信息
Immunogen sequence: DGINSLERKL KRRLEREGLS SERWERVKKM RTPKKKKIKL SHPKDMNNFK LERERSYELV RSAETHSLPS DTSYSEQEDS E
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 91%.
靶标信息
KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(4) demethylase 5B; Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; jumonji, AT rich interactive domain 1B; Jumonji/ARID domain-containing protein 1B; lysine (K)-specific demethylase 5B; Lysine-specific demethylase 5B; PLU-1; protein phosphatase 1, regulatory subunit 98; putative DNA/chromatin binding motif; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A
基因别名: CT31; JARID1B; KDM5B; PLU-1; PLU1; PPP1R98; PUT1; RBBP2H1; RBBP2H1A; RBP2-H1
UniProt ID: (Human) Q9UGL1
Entrez Gene ID: (Human) 10765
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
zinc ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
histone demethylase activity
histone demethylase activity (H3-K4 specific)
histone demethylase activity (H3-trimethyl-K4 specific)
histone demethylase activity (H3-dimethyl-K4 specific)
histone modifying enzyme
transcription, DNA-templated
single fertilization
post-embryonic development
positive regulation of gene expression
positive regulation of mammary gland epithelial cell proliferation
histone H3-K4 demethylation
histone H3-K4 demethylation, trimethyl-H3-K4-specific
cellular response to fibroblast growth factor stimulus
negative regulation of transcription, DNA-templated
rhythmic process
oxidation-reduction process
branching involved in mammary gland duct morphogenesis
mammary duct terminal end bud growth
response to fungicide
uterus morphogenesis
lens fiber cell differentiation
regulation of estradiol secretion
