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Immunogen sequence: CLVLGYMAK DKFRRMNEGQ VYSFSQQPQD QVVVSGQPVT LLCAIPEYDG FVLWIKDGLA LGVGRDLSSY PQYLVVGNHL SGEHHLKILR AELQDDAVYE CQAIQAAIRS RPARLTVLVP PDDPVILGGP VISLRAGDPL NLTCHADNAK PAASIIWLRK GEVINGATYS KTLLRDGKRE SIVSTLFISP GDVENGQSIV CRATNKAIPG GKETSVTIDI QHPPLVNLSV EPQPVLEDNV VTFHCSAKAN PAVTQYRWAK RGQIIKEASG EVYRTTVDYT YFSEPVSCEV TNALGSTNLS RTVDVYFGPR MTTEPQSLLV DLGSDAIFSC AWTGNPSLTI VWMKRGSGVV LSNEK (28-381 aa encoded by B C101801)
The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; membrane protein mKirre; mKirre; nephrin-like 2; Nephrin-like protein 2; X kin of IRRE like 3
基因别名: 1500010O20Rik; 2900036G11Rik; KIAA1867; KIRRE; KIRREL3; mKIAA1867; MRD4; NEPH2; PRO4502; SST4; UNQ5923/PRO4502/PRO19814
UniProt ID: (Human) Q8IZU9, (Mouse) Q8BR86
Entrez Gene ID: (Human) 84623, (Mouse) 67703, (Rat) 315546