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Immunogen sequence: MNSLVSWQL LLFLCATHFG EPLEKVASVG NSRPTGQQLE SLGLLAPGEQ SLPCTERKPA ATARLSRRGT SLSPPPESSG SPQQPGLSAP HSRQIPAPQG AVLVQREKDL PNYNWNSFGL RFGKREAAPG NHGRSAGRG (1-138 aa encoded by BC022819 )
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 0610012C01Rik; Kiss1 metastasis-suppressor; Kisspeptin-1; malignant melanoma metastasis-suppressor; Metastasis-suppressor KiSS-1; metastin; prepro-kisspeptin
基因别名: HH13; KiSS-1; KISS1; kisspeptin; metastatin; PP5098
UniProt ID: (Human) Q15726, (Mouse) Q6Y4S4
Entrez Gene ID: (Human) 3814, (Mouse) 280287