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产品信息
PA5-33880
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human KISS1R / GPR54.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551249
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Monkey (94%) Mouse, Rat, Bat (83%).
靶标信息
GCPR54 is a galanin-like G protein coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the protein suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that it appears to play a role in the onset of puberty. GPR54 has been reported in various human brain regions, placenta, pancreas, and spinal cord, and at lower levels in spleen, peripheral blood leukocytes, testis, lymph node, thymus, small intestine, stomach, lung, and kidney. The receptor is also abundant in tumor tissues. In rat, GPR54 is expressed in liver, intestine, and in the pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex (including frontal), and striatum. ESTs have been isolated from normal placenta and kidney cancer libraries.
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生物信息学
蛋白别名: G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; KiSS-1 receptor; KiSS-1R; Kisspeptins receptor; Metastin receptor
基因别名: AXOR12; CPPB1; GPR54; HH8; HOT7T175; KISS-1R; KISS1R
UniProt ID: (Human) Q969F8
Entrez Gene ID: (Human) 84634
activation of MAPKK activity
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
negative regulation of cell proliferation
calcium-mediated signaling
positive regulation of hormone secretion
arachidonic acid secretion
positive regulation of synaptic transmission
positive regulation of stress fiber assembly
