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KLB Antibody (PA5-44023) in IHC
Immunohistochemistry analysis of human testis tissue using an anti-KLB polyclonal antibody (Product # PA5-44023).
产品信息
PA5-44023
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human KLB
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2606932
产品详细信息
Peptide sequence: DAYTIRRGLF YVDFNSKQKE RKPKSSAHYY KQIIRENGFS LKESTPDVQG
Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 85%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%
靶标信息
KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-klotho; betaKlotho; BKL; klotho beta like; Klotho beta-like protein; MGC142213
基因别名: BKL; KLB
UniProt ID: (Human) Q86Z14
Entrez Gene ID: (Human) 152831
MAPK cascade
carbohydrate metabolic process
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
glycosyl compound metabolic process
