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Cytokeratin 14/16 Antibody (PA5-99310) in IHC (P)
Immunohistochemistry analysis of Cytokeratin 14/16 in human colon cancer tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Cytokeratin 14/16 polyclonal antibody (Product # PA5-99310) using a dilution of 1:100 (1.5 hours at 22°C) followed by HRP conjugated goat anti-rabbit secondary antibody.
产品信息
PA5-99310
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KRT14(Accession P02533), corresponding to amino acid residues M1-A36.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2818243
产品详细信息
Antibody detects endogenous levels of total Cytokeratin 14/16.
靶标信息
In Bowen's disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CK 14; CK 16; CK-14; CK-16; cytokeratin 14; cytokeratin 16; Cytokeratin-14; Cytokeratin-16; Cytokeratin14; Cytokeratin16; epidermolysis bullosa simplex, Dowling-Meara, Koebner; focal non-epidermolytic palmoplantar keratoderma; K14; K16; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 16, type I; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 16; keratin intermediate filament 16a; keratin intermediate filament 16b; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 16; Keratin-14; Keratin-16; Type I keratin Ka14; type I keratin KA16
基因别名: AI324768; AI626930; CK14; CK16; EBS3; EBS4; FNEPPK; K14; K16; K1CP; Ka14; Ka16; Krt-1.14; Krt1-14; Krt1-16; KRT14; KRT16; KRT16A; NEPPK; NFJ; PC1
UniProt ID: (Human) P02533, (Human) P08779, (Mouse) Q61781, (Rat) Q6IFV1, (Mouse) Q9Z2K1
Entrez Gene ID: (Human) 3861, (Human) 3868, (Mouse) 16664, (Rat) 287701, (Mouse) 16666, (Rat) 303530
morphogenesis of an epithelium
immune system process
inflammatory response
aging
keratinocyte differentiation
negative regulation of cell migration
keratinization
hair cycle
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
epithelial cell differentiation
intermediate filament bundle assembly
epidermis development
response to zinc ion
response to ionizing radiation
hemidesmosome assembly
biological_process
cytoskeleton organization
cell proliferation
