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The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ghHb1; ghHKb1; Hair keratin K2.9; hard keratin, type II, 1; K81; keratin 81, type II; keratin complex 2, basic, gene 19; Keratin, hair, basic, 1; Keratin, type II cuticular Hb1; Keratin-81; krt81; Metastatic lymph node 137 gene protein; MLN 137; Type II hair keratin Hb1; Type-II keratin Kb21
基因别名: AA589625; ghHkb1; Hb-1; HB1; hHAKB2-1; Krt2-19; KRT81; KRTHB1; MLN137
UniProt ID: (Human) Q14533, (Mouse) Q9ERE2
Entrez Gene ID: (Human) 3887, (Mouse) 64818