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KSHV ORF45 Antibody (MA5-14769) in ICC/IF
Immunocytochemistry analysis of TPA induced BCBL-1 cells (A) and uninduced BCBL-1 cells (B) using KSHV ORF45 monoclonal antibody (Product # MA5-14769) followed with AEC staining.
产品信息
MA5-14769
应用
建议稀释比
已发表文章
产品规格
种属反应
Virus
已发表种属
Virus
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2D4A5
抗原
Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
偶联物
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10999794
产品详细信息
MA5-14769 targets KSHV ORF45 in indirect ELISA, IHC and WB applications and shows reactivity with Virus samples.
The MA5-14769 immunogen is purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
靶标信息
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Kaposi's Sarcoma Virus; Kaposi's sarcoma-associated herpesvirus
