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Positive test controls include: U-251MG, HeLa, Jurkat, mouse brain, mouse spleen, mouse testis, mouse kidney, mouse lung, rat brain. The target is usually found in the following locations: Cytoplasm, Endoplasmic reticulum membrane, Membrane, Peripheral membrane protein.
Immunogen sequence: SSPAPFPTSS NPSSATTPPN PSPGQRDSRF NFPAAYFIHH RQQFIFPVPS AGHCWKCLLI AESLKENAFN ISAFAHAAPL PEAADGTRLD DQPKADVLEA H
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt]
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CAP kinase; HB protein; kinase KSR1; Kinase suppressor of Ras 1; mKSR1; OTTHUMP00000162931; Protein Hb
基因别名: AW492498; B-KSR1; D11Bhm183e; D11Bhm184e; hb; KSR; KSR1; RSU2
UniProt ID: (Human) Q8IVT5, (Mouse) Q61097
Entrez Gene ID: (Human) 8844, (Mouse) 16706, (Rat) 360573