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GCPR54 is a galanin-like G protein coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the protein suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that it appears to play a role in the onset of puberty. GPR54 has been reported in various human brain regions, placenta, pancreas, and spinal cord, and at lower levels in spleen, peripheral blood leukocytes, testis, lymph node, thymus, small intestine, stomach, lung, and kidney. The receptor is also abundant in tumor tissues. In rat, GPR54 is expressed in liver, intestine, and in the pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex (including frontal), and striatum. ESTs have been isolated from normal placenta and kidney cancer libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; hOT7T175; Hypogonadotropin-1; kiSS-; KiSS-1 receptor; KiSS-1R; Kisspeptins receptor; Metastin receptor; mOT7T175; orphan G protein-coupled receptor 54; orphan G protein-coupled receptor GPR54; rOT7T175
基因别名: AXOR12; CPPB1; GPR54; HH8; HOT7T175; KiSS-1; KISS-1R; KISS1R
UniProt ID: (Human) Q969F8, (Mouse) Q91V45, (Rat) Q924U1
Entrez Gene ID: (Human) 84634, (Mouse) 114229, (Rat) 78976