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产品信息
66123-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
10E8D11
抗原
Kininogen 1 Fusion Protein Ag19233 (20-374 aa encoded by BC060039)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ESQSEEIDC NDKDLFKAVD AALKKYNSQN QSNNQFVLYR ITEATKTVGS DTFYSFKYEI KEGDCPVQSG KTWQDCEYKD AAKAATGECT ATVGKRSSTK FSVATQTCQI TPAEGPVVTA QYDCLGCVHP ISTQSPDLEP ILRHGIQYFN NNTQHSSLFM LNEVKRAQRQ VVAGLNFRMT YSIVQTNCSK ENFLFLTPDC KSLWNGDTGE CTDNAYIDIQ LRIASFSQNC DIYPGKDFVQ PPTKICVGCP RDIPTNSPEL EETLTHTITK LNAENNATFY FKIDNVKKAR VQVVAGKKYF IDFVARETTC SKESNEELTE SCETKKLGQS LDCNAEVYVV PWEKKIYPTV NCQPLG (20-374 aa encoded by BC060039)
靶标信息
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-2-thiol proteinase inhibitor; bradykinin; Fitzgerald factor; High molecular weight kininogen; HMWK; Kininogen-1; Williams-Fitzgerald-Flaujeac factor
基因别名: BDK; BK; KNG; KNG1
UniProt ID: (Human) P01042
Entrez Gene ID: (Human) 3827
platelet degranulation
smooth muscle contraction
inflammatory response
negative regulation of cell adhesion
positive regulation of cytosolic calcium ion concentration
blood coagulation, intrinsic pathway
negative regulation of endopeptidase activity
negative regulation of blood coagulation
positive regulation of urine volume
positive regulation of renal sodium excretion
vasodilation
positive regulation of apoptotic process
negative regulation of proteolysis
